Furatsilin

Antimicrobial agent, nitrofuran derivative. Bacterial flavoproteins, reducing the 5-nitro group, form highly reactive amino derivatives that can cause conformational changes in proteins (including ribosomal ones) and other macromolecules, leading to the death of bacteria

Registration number: ЛП-008334

Trade name:  Furacilin 

International nonproprietary or generic name:  nitrofural

Dosage form:  powder for the preparation of a solution for local and external use    

Compound

Active ingredient: nitrofural (furatsilin) – 20 mg.
Excipient: sodium chloride – 800 mg

Description:

yellow or greenish-yellow powder  

Pharmacotherapeutic group:  antimicrobial agent – nitrofuran

Code ATX:  D08AF01

Pharmacological properties

Pharmacodynamics

Antimicrobial agent, nitrofuran derivative. Bacterial flavoproteins, by reducing the 5-nitro group, form highly reactive amino derivatives that can cause conformational changes in proteins (including ribosomal ones) and other macromolecules, leading to the death of bacteria.

Active against gram-positive and gram-negative bacteria (including Staphylococcus spp., Streptococcus spp., Escherichia coli, Clostridium perfringens). Resistance develops slowly and does not reach a high degree. 

Pharmacokinetics

When applied externally and locally, absorption is negligible. Penetrates through histohematic barriers and is evenly distributed in liquids and tissues. The main route of metabolism is the reduction of the nitro group. Excreted by the kidneys and partially with bile 

Indications for use

Locally:  blepharitis, conjunctivitis, osteomyelitis, empyema of the paranasal sinuses and pleura; urinary tract infections - rinsing cavities; acute tonsillitis, stomatitis, gingivitis
Externally:  purulent wounds, bedsores, II - III degree burns, minor skin damage (including abrasions, scratches, cracks, cuts)

Contraindications

Hypersensitivity to nitrofural, nitrofuran derivatives and/or other components of the drug, bleeding, allergic dermatoses, severe renal dysfunction.

Use during pregnancy and breastfeeding: use during pregnancy and breastfeeding is possible if the expected benefit to the mother outweighs the potential risk to the fetus or child 

Directions for use and doses

Locally, externally in the form of a 0.02% freshly prepared aqueous solution: immediately before use, one packet (20 mg of furatsilin) is dissolved in 100 ml of warm boiled water. For faster dissolution, hot or boiling water is recommended. The solution is then cooled to room temperature.  

Locally. Blepharitis, conjunctivitis - instillation of an aqueous 0.02% solution into the conjunctival sac. Osteomyelitis after surgery - rinsing the cavity followed by applying a wet bandage. Empyema of the paranasal sinuses (including sinusitis) - washing the cavity, empyema of the pleura - after removing the pus, wash the pleural cavity and inject 20-100 ml of an aqueous 0.02% solution.

To wash the urethra and bladder, use an aqueous 0.02% solution with an exposure of 20 minutes. For tonsillitis, stomatitis, gingivitis - rinse the mouth and throat with 100 ml of an aqueous 0.02% solution 2-3 times a day. 

The duration of treatment  is as indicated, depending on the nature and location of the affected area. If symptoms persist, it is recommended to consult a doctor.

Externally. In the form of an aqueous 0.02% solution, irrigate wounds and apply wet bandages.

Side effect

Allergic reactions, dermatitis, and skin itching are possible. If any of the side effects indicated in the instructions are aggravated or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.

Overdose

To date, no cases of overdose have been observed.

Interaction with other drugs

has not been studied.

special instructions

not studied

Impact on the ability to drive vehicles and machinery

The drug does not affect the ability to drive or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Release form  

Powder for preparing a solution for local and external use, 20 mg.

820 mg in heat-sealable bags made of a combined material.

1, 2, 3, 4, 5, 10, 12, 15, 20 packages along with instructions for use are placed in a cardboard pack.

Storage conditions 

At a temperature not exceeding 25°C. Keep out of the reach of children

Best before date  

3 years. Do not use after the expiration date.  

Vacation conditions

Available without a prescription.